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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM393332
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
55±n/a nM
Citation
Malamas, M; Makriyannis, A; Subramanian, KV; Whitten, KM; Zvonok, NM; West, JM; Mccormack, M; Pavlopoulos, S N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof US Patent US9963444 Publication Date 5/8/2018
More Info.:
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
Inhibitor
Name:
BDBM393332
Synonyms:
4'-(((1S,3S)-3-isothiocyanatocyclobutoxy)methyl)-3-methoxy-1,1'-biphenyl | US9963444, Example 35
Type:
Small organic molecule
Emp. Form.:
C19H19NO2S
Mol. Mass.:
325.425
SMILES:
COc1cccc(c1)-c1ccc(CO[C@H]2C[C@H](C2)N=C=S)cc1 |r,wU:14.14,16.19,(-8.28,-5.55,;-6.94,-4.78,;-6.94,-3.24,;-8.28,-2.47,;-8.28,-.93,;-6.94,-.16,;-5.61,-.93,;-5.61,-2.47,;-4.28,-.16,;-2.94,-.93,;-1.61,-.16,;-1.61,1.38,;-.28,2.15,;1.06,1.38,;2.39,2.15,;2.79,3.64,;4.28,3.24,;3.88,1.75,;5.61,4.01,;6.94,4.78,;8.28,5.55,;-2.94,2.15,;-4.28,1.38,)|