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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM393349
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
55±n/a nM
Citation
 Malamas, M; Makriyannis, A; Subramanian, KV; Whitten, KM; Zvonok, NM; West, JM; Mccormack, M; Pavlopoulos, S N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof US Patent  US9963444 Publication Date 5/8/2018 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM393349
Synonyms:
3-Fluoro-4'-((1R,3R)-3-isothiocyanatocyclobutoxy)-4-methoxy-1,1'-biphenyl | US9963444, Example 51
Type:
Small organic molecule
Emp. Form.:
C18H16FNO2S
Mol. Mass.:
329.389
SMILES:
COc1ccc(cc1F)-c1ccc(O[C@H]2C[C@@H](C2)N=C=S)cc1 |r,wU:16.19,wD:14.14,(-8.95,-3.24,;-7.61,-4.01,;-6.28,-3.24,;-6.28,-1.7,;-4.94,-.93,;-3.61,-1.7,;-3.61,-3.24,;-4.94,-4.01,;-4.94,-5.55,;-2.28,-.93,;-.94,-1.7,;.39,-.93,;.39,.61,;1.72,1.38,;3.06,2.15,;4.55,1.75,;4.94,3.24,;3.46,3.64,;6.28,4.01,;7.61,4.78,;8.95,5.55,;-.94,1.38,;-2.28,.61,)|
Structure:
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