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Target
P2X purinoceptor 4
Ligand
BDBM393615
Substrate
n/a
Meas. Tech.
Antagonist Activity Assay
IC50
64±0.0 nM
Citation
 Ushioda, M; Kobayashi, K; Saito, D; Sakuma, S; Imai, T; Inoue, K P2X4 receptor antagonist US Patent  US9969700 Publication Date 5/15/2018 
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM393615
Synonyms:
US09969700, 173
Type:
Small organic molecule
Emp. Form.:
C26H20ClN3O4S
Mol. Mass.:
505.973
SMILES:
Clc1ccccc1CS(=O)(=O)Nc1ccc(cc1)N1c2ccc3ccccc3c2NC(=O)CC1=O
Structure:
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