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Target
Kappa-type opioid receptor
Ligand
BDBM394118
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
301±9.79 nM
Citation
 Tafesse, L; Yao, J; Yu, J; Goehring, RR Benzomorphan analogs and use thereof US Patent  US9975854 Publication Date 5/22/2018 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM394118
Synonyms:
(2R,6S,11R)-3,6-dimethyl-11- ((4-(methylsulfonyl)- phenethyl)amino)-1,2,3,4,5,6- hexahydro-2,6-methano- benzo[d]azocin-8-ol | US9975854, Compound 10
Type:
Small organic molecule
Emp. Form.:
C23H30N2O3S
Mol. Mass.:
414.561
SMILES:
CN1CC[C@@]2(C)[C@@H](NCCc3ccc(cc3)S(C)(=O)=O)[C@H]1Cc1ccc(O)cc21 |r,TLB:0:1:6:28.22.21|
Structure:
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