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Target
Bromodomain-containing protein 4 [349-460]
Ligand
BDBM259880
Substrate
n/a
Meas. Tech.
in vitro kinase inhibition assay
IC50
2310±n/a nM
Citation
 Durden, DL; Morales, GA; Garlich, JR Thienopyranones as kinase and epigenetic inhibitors US Patent  US10308662 Publication Date 6/4/2019 
Target
Name:
Bromodomain-containing protein 4 [349-460]
Synonyms:
BRD4 | BRD4 bromodomain 2 | BRD4_HUMAN | Brd4-2 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13087.06
Organism:
Homo sapiens (Human)
Description:
O60885[349-460]
Residue:
112
Sequence:
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM259880
Synonyms:
US10308662, Compound 121 | US9505780, 121
Type:
Small organic molecule
Emp. Form.:
C30H21F3IN3O4S
Mol. Mass.:
703.47
SMILES:
Fc1ccc(C(=O)Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)c(Nc2ccc(I)cc2F)c1F
Structure:
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