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Target
Ghrelin O-acyltransferase
Ligand
BDBM396165
Substrate
n/a
Meas. Tech.
hGOAT Activity in HEK293 Cells after Incubation
IC50
0.110±n/a nM
Citation
 Godbout, C; Trieselmann, T; Vintonyak, V Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors US Patent  US10308667 Publication Date 6/4/2019 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM396165
Synonyms:
6-[6-Amino-5-(2,4-dimethyl-2H-pyrazol-3-yl)-pyridin-2-ylmethyl]-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-ylamine | US10308667, Example 68
Type:
Small organic molecule
Emp. Form.:
C17H18N8O
Mol. Mass.:
350.3778
SMILES:
Cc1cnn(C)c1-c1ccc(Cc2c(C)nc3nonc3c2N)nc1N |(6.53,.81,;6.13,-.68,;7.04,-1.93,;6.13,-3.17,;4.67,-2.69,;3.33,-3.47,;4.67,-1.15,;3.33,-.38,;2,-1.15,;.67,-.38,;.67,1.15,;-.67,1.93,;-2,1.15,;-2,-.38,;-.67,-1.15,;-3.33,-1.15,;-4.67,-.38,;-6.13,-.86,;-7.04,.38,;-6.13,1.63,;-4.67,1.15,;-3.33,1.93,;-3.33,3.47,;2,1.93,;3.33,1.15,;4.67,1.93,)|
Structure:
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