Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM397094
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
10000±n/a nM
Citation
Kuduk, SD; Liverton, N; Reger, TS; Skudlarek, JW 5,5-bicyclic oxazole orexin receptor antagonists US Patent US9987255 Publication Date 6/5/2018
More Info.:
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
Inhibitor
Name:
BDBM397094
Synonyms:
2-{5-methyl-2-[5-{[2-(1- methylethoxy)pyriddin-3- yl]carbonyl}hexahydropyrrolo [3,4-c]pyrrol-2(1H)-yl]-1,3- oxazol-4-yl}propan-2-ol | US9987255, 8
Type:
Small organic molecule
Emp. Form.:
C22H30N4O4
Mol. Mass.:
414.498
SMILES:
CC(C)Oc1ncccc1C(=O)N1CC2CN(CC2C1)c1nc(c(C)o1)C(C)(C)O