Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM397102
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
3069±n/a nM
Citation
 Kuduk, SD; Liverton, N; Reger, TS; Skudlarek, JW 5,5-bicyclic oxazole orexin receptor antagonists US Patent  US9987255 Publication Date 6/5/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM397102
Synonyms:
2-{2-[5-{[4-fluoro-2-(2H-1,2,3- triazol-2-yl) phenyl]carbonyl}hexahydropyrrolo [3,4-c]pyrrol-2(1H)-yl]-5-methyl- 1,3-oxazol-4-yl}propan-2-ol | US9987255, 16
Type:
Small organic molecule
Emp. Form.:
C22H25FN6O3
Mol. Mass.:
440.4707
SMILES:
Cc1oc(nc1C(C)(C)O)N1CC2CN(CC2C1)C(=O)c1ccc(F)cc1-n1nccn1
Structure:
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