Target
Tyrosine-protein kinase ITK/TSK
Ligand
BDBM397208
Substrate
n/a
Meas. Tech.
Omnia Assay
IC50
<10±n/a nM
Citation
 Singh, JPetter, RCTester, RWKluge, AFMazdiyasni, HWestlin, III, WFNiu, DQiao, L Substituted 2,4-diaminopyrimidines as kinase inhibitors US Patent  US9987276 Publication Date 6/5/2018 
Target
Name:
Tyrosine-protein kinase ITK/TSK
Synonyms:
EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:
Protein
Mol. Mass.:
71839.20
Organism:
Homo sapiens (Human)
Description:
Q08881
Residue:
620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
  
Inhibitor
Name:
BDBM397208
Synonyms:
US10596172, Compound I-153 | US10828300, Compound I-153 | US11351168, Compound I-153 | US9987276, Compound I-153
Type:
Small organic molecule
Emp. Form.:
C24H21N7O3
Mol. Mass.:
455.4686
SMILES:
CC(=O)c1cnc(Nc2ccc3[nH]ncc3c2)nc1Nc1ccc2OCCN(C(=O)C=C)c2c1
Structure:
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