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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM31587
Substrate
GSK-3 beta Substrate Peptide
Meas. Tech.
GSK-3beta Kinase Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
2.3±n/a nM
Citation
 Saitoh, M; Kunitomo, J; Kimura, E; Hayase, Y; Kobayashi, H; Uchiyama, N; Kawamoto, T; Tanaka, T; Mol, CD; Dougan, DR; Textor, GS; Snell, GP; Itoh, F Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorg Med Chem 17:2017-29 (2009) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM31587
Synonyms:
oxadiazole derivative, 20x
Type:
Small organic molecule
Emp. Form.:
C24H17N5O2S
Mol. Mass.:
439.489
SMILES:
COc1ccc(cc1)-n1cnc2ccc(cc12)-c1nnc(SCc2cccc(c2)C#N)o1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
GSK-3 beta Substrate Peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2656.00
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
RRRPASVPPSPSLSRHSPSHQRR