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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM397531
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
30±n/a nM
Citation
 Wu, L; Yao, W Cyclopropylamines as LSD1 inhibitors US Patent  US9994546 Publication Date 6/12/2018 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM397531
Synonyms:
1-Phenyl-4-(3-{[(trans-2-phenylcyclopropyl)amino]methyl}azetidin-1-yl)cyclohexanecarbonitrile | US10676457, Example 30 | US11155532, Example 30 | US9994546, Example 30
Type:
Small organic molecule
Emp. Form.:
C26H31N3
Mol. Mass.:
385.5444
SMILES:
N#CC1(CCC(CC1)N1CC(CNC2CC2c2ccccc2)C1)c1ccccc1 |(6.45,-5.34,;5.63,-4.04,;4.82,-2.73,;4.82,-1.19,;3.48,-.42,;2.15,-1.19,;2.15,-2.73,;3.48,-3.5,;.81,-.42,;.42,1.07,;-1.07,.67,;-2.41,1.44,;-3.74,.67,;-5.07,1.44,;-6.61,1.44,;-5.84,2.77,;-5.84,4.31,;-7.18,5.08,;-7.18,6.62,;-5.84,7.39,;-4.51,6.62,;-4.51,5.08,;-.67,-.82,;6.35,-2.78,;7.17,-1.48,;8.71,-1.53,;9.43,-2.89,;8.62,-4.2,;7.08,-4.14,)|
Structure:
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