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Target
Serine/threonine-protein kinase TBK1
Ligand
BDBM397727
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
15.8±n/a nM
Citation
 Bigi, S; Keung, W; Swann, S; Vu, PH; Woodhead, SJ; Gangloff, AR Heteroarylamide inhibitors of TBK1 US Patent  US9994547 Publication Date 6/12/2018 
Target
Name:
Serine/threonine-protein kinase TBK1
Synonyms:
NAK | NF-kappa-B-activating kinase | Protein cereblon/Serine/threonine-protein kinase TBK1 | T2K | TANK-binding kinase 1 (TBK-1) | TANK-binding kinase 1 (TBK1) | TBK1 | TBK1_HUMAN
Type:
protein
Mol. Mass.:
83645.20
Organism:
Homo sapiens (Human)
Description:
Q9UHD2
Residue:
729
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
  
Inhibitor
Name:
BDBM397727
Synonyms:
(S)-N-(5-(6-cyano-5-((2-oxo-2-(2-(trifluoromethyl)oxazolidin-3-yl)ethyl)amino)pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide | US9994547, Example 96
Type:
Small organic molecule
Emp. Form.:
C19H18FN7O3
Mol. Mass.:
411.3897
SMILES:
F[C@@H]1OCCN1C(=O)CNc1cc(cnc1C#N)-c1cnc(NC(=O)C2CC2)cn1 |r|
Structure:
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