Reaction Details Report a problem with these data
Target
Putative hydrolase
Ligand
BDBM50327827
Substrate
n/a
Meas. Tech.
Biochemical Characterization of Cif Inhibitors
IC50
40000±6000 nM
Citation
 Madden, DR; Bahl, CD; Hammock, BD; Morisseau, C Compounds and methods for inhibiting Cif virulence factor US Patent  US10322118 Publication Date 6/18/2019 
Target
Name:
Putative hydrolase
Synonyms:
CFTR inhibitory factor, Cif | Putative hydrolase | cif
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35786.52
Organism:
Pseudomonas aeruginosa (strain UCBPP-PA14)
Description:
A0A0H2ZD27
Residue:
319
Sequence:
MILDRLCRGLLAGIALTFSLGGFAAEEFPVPNGFESAYREVDGVKLHYVKGGQGPLVMLVHGFGQTWYEWHQLMPELAKRFTVIAPDLPGLGQSEPPKTGYSGEQVAVYLHKLARQFSPDRPFDLVAHDIGIWNTYPMVVKNQADIARLVYMEAPIPDARIYRFPAFTAQGESLVWHFSFFAADDRLAETLIAGKERFFLEHFIKSHASNTEVFSERLLDLYARSYAKPHSLNASFEYYRALNESVRQNAELAKTRLQMPTMTLAGGGHGGMGTFQLEQMKAYAEDVEGHVLPGCGHWLPEECAAPMNRLVIDFLSRGR
  
Inhibitor
Name:
BDBM50327827
Synonyms:
1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)urea | CHEMBL1258106 | US10322118, Urea-Based Scaffold Entry 10 | US9296693, 20
Type:
Small organic molecule
Emp. Form.:
C15H20N4O4
Mol. Mass.:
320.3437
SMILES:
CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure:
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