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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32108
Substrate
cy3B-GM
Meas. Tech.
Tumor Hsp90 Inhibitors Dose Response Confirmation
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
10892.1±n/a nM
Citation
 PubChem, PC Tumor Hsp90 Inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32108
Synonyms:
6-keto-7,8,9,10-tetrahydrophenothiazine-3-carboxylic acid methyl ester | 6-oxo-7,8,9,10-tetrahydrophenothiazine-3-carboxylic acid methyl ester | MLS000100349 | SMR000082651 | cid_1258835 | methyl 4-oxo-2,3,4,10-tetrahydro-1H-phenothiazine-7-carboxylate | methyl 6-oxidanylidene-7,8,9,10-tetrahydrophenothiazine-3-carboxylate | methyl 6-oxo-7,8,9,10-tetrahydrophenothiazine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H13NO3S
Mol. Mass.:
275.323
SMILES:
COC(=O)c1ccc2N=C3CCCC(=O)C3Sc2c1 |t:8|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
cy3B-GM
Synonyms:
fluorescently (Cy3B) labeled geldanamycin
Type:
fluorescent probe
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA