Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM32391
Substrate
Plasmepsin Substrate Peptide
Meas. Tech.
Enzyme Inhibition Assay
pH
4.5±n/a
Temperature
296.15±n/a K
Ki
6800±n/a nM
Km
63000±n/a nM
Citation
 Blum, A; Böttcher, J; Sammet, B; Luksch, T; Heine, A; Klebe, G; Diederich, WE Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors. Bioorg Med Chem 16:8574-86 (2008) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM32391
Synonyms:
iso-butyl-substituted sulfonamide, 9b
Type:
Small organic molecule
Emp. Form.:
C24H39N5O4S2
Mol. Mass.:
525.728
SMILES:
CC(C)CN(CCNCCN(CC(C)C)S(=O)(=O)c1ccc(N)cc1)S(=O)(=O)c1ccc(N)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Plasmepsin Substrate Peptide
Synonyms:
n/a
Type:
fluorogenic substrate
Mol. Mass.:
2590.28
Organism:
n/a
Description:
n/a
Residue:
23
Sequence:
ATHRILENLEPNPHEGLNARGNH