Reaction Details Report a problem with these data
Target
Vascular endothelial growth factor A
Ligand
BDBM107710
Substrate
n/a
Meas. Tech.
VEGF ELISA Assay
EC50
3300±n/a nM
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and methods of use US Patent  USRE47437 Publication Date 6/18/2019 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
395
Sequence:
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM107710
Synonyms:
US11426393, Compound Table XV.16 | US8598210, Table XV, 16 | US8722895, 16: {[5-(2-Methyl-5-chlorophenyl)-3- hydroxypyridine-2-carbonyl]amino}-acetic acid | US9598370, Example 00141 | USRE47437, Example {[5-(2-Methyl-5-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-aceticacid
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O4
Mol. Mass.:
320.728
SMILES:
Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: