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Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM246869
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<10±n/a nM
Citation
 Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US9999619 Publication Date 6/19/2018 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM246869
Synonyms:
4-{3-(Cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]azetidin-1-yl}-N- [4-fluoro-2- (trifluoromethyl) phenyl]piperidine-1- carboxamide | US10053465, 8 | US10065963, Compound 8 | US10125150, Example 8 | US10336759, # 8 | US10479803, Example 8 | US10519163, Example 8 | US10675284, Example 8 | US11084822, Example 8 | US11130767, # 8 | US11136326, Example 8 | US11285140, Example 154 | US11304949, Compound 2 | US11324749, Comp. No. 2 | US11406640, Comp. No. 2 | US11596632, Comp. No. 2 | US20240058343, Compound 2 | US9732097, Example 8 | US9999619, Example 154
Type:
Small organic molecule
Emp. Form.:
C27H25F4N9O
Mol. Mass.:
567.5407
SMILES:
Fc1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(c1)C(F)(F)F
Structure:
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