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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34763
Substrate
Mannose-6-phosphate
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
>50000±0 nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34763
Synonyms:
6-Methyl-nicotinic acid [1-[5-(2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-hydrazide | 6-methyl-N-[[5-(2-nitrophenyl)-2-furanyl]methylideneamino]-3-pyridinecarboxamide | 6-methyl-N-[[5-(2-nitrophenyl)-2-furyl]methyleneamino]nicotinamide | 6-methyl-N-[[5-(2-nitrophenyl)furan-2-yl]methylideneamino]pyridine-3-carboxamide | MLS000591138 | SMR000217958 | cid_1418917
Type:
Small organic molecule
Emp. Form.:
C18H14N4O4
Mol. Mass.:
350.3282
SMILES:
Cc1ccc(cn1)C(=O)N\N=C\c1ccc(o1)-c1ccccc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Mannose-6-phosphate
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA