Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM400858
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Li, Y; Burns, DM; Feng, H; Huang, T; Mei, S; Pan, J; Ye, H; Zhu, W; Rafalski, M; Wang, A; Xue, C Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors US Patent  US10000507 Publication Date 6/19/2018 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM400858
Synonyms:
2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-yl]-6-phenylthieno[3,2-b]pyridine-3-carboxamide | US10000507, Example 25
Type:
Small organic molecule
Emp. Form.:
C24H27N7OS
Mol. Mass.:
461.582
SMILES:
Cn1ncc(NC(=O)c2c(N)sc3cc(cnc23)-c2ccccc2)c1N1CCCC(N)CC1
Structure:
Search PDB for entries with ligand similarity: