Reaction Details Report a problem with these data
Target
Sodium/glucose cotransporter 1
Ligand
BDBM402293
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
1.49±n/a nM
Citation
 Zhong, H; Liao, J; Yu, H; Xu, Y; Li, Q; Chen, J; Gao, P; Tan, S; Wang, S C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof US Patent  US10011627 Publication Date 7/3/2018 
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
  
Inhibitor
Name:
BDBM402293
Synonyms:
US10011627, 9
Type:
Small organic molecule
Emp. Form.:
C24H28O8
Mol. Mass.:
444.4743
SMILES:
CCc1ccc(cc1Cc1ccc2OCCOc2c1)[C@]12OC[C@](CO)(O1)[C@@H](O)[C@H](O)[C@H]2O |TLB:29:28:21.20:25,THB:27:26:21.20:25,31:30:21.20:25|
Structure:
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