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Target
Mitogen-activated protein kinase 14
Ligand
BDBM36489
Substrate
n/a
Meas. Tech.
Fluorescence-Based Competition Assay
pH
7±0
IC50
5.61e+3±n/a nM
Citation
 Chen, J; Zhang, Z; Stebbins, JL; Zhang, X; Hoffman, R; Moore, A; Pellecchia, M A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors. ACS Chem Biol 2:329-36 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM36489
Synonyms:
BI-12H11
Type:
Small organic molecule
Emp. Form.:
C20H23N3O2S2
Mol. Mass.:
401.546
SMILES:
CN1SC(=C)c2cc(ccc12)S(=O)(=O)Nc1ccccc1N1CCCCC1
Structure:
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