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Target
Sodium/bile acid cotransporter
Ligand
BDBM400123
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
112±n/a nM
Citation
 Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF US Patent  US20230270719 Publication Date 8/31/2023 
Target
Name:
Sodium/bile acid cotransporter
Synonyms:
Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1
Type:
PROTEIN
Mol. Mass.:
38131.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_838517
Residue:
349
Sequence:
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
  
Inhibitor
Name:
BDBM400123
Synonyms:
7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)-2-oxoacetyl)-N-(3,5-dichlorophenyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide | US10328053, Compound 102 | US10874640, Compound 102 | US20230270719, Compound 102
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2N6O3
Mol. Mass.:
487.339
SMILES:
Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(Cl)cc(Cl)c1
Structure:
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