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Target
Tyrosine-protein kinase BTK
Ligand
BDBM264143
Substrate
n/a
Meas. Tech.
Human Recombinant Btk Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2.30±n/a nM
Comments
extracted
Citation
 Ko, SS; Batt, DG; Bertrand, MB; Delucca, G; Langevine, CM; Liu, Q; Srivastava, AS; Watterson, SH Carbazole carboxamide compounds US Patent  US9714234 Publication Date 7/25/2017 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM264143
Synonyms:
4-(3-(5-Fluoro-1,3-dioxo-1H-pyrido[1,2-c]pyrimidin-2(3H)-yl)-2-methylphenyl)-7-(methoxymethyl)-9H-carbazole-1-carboxamide (Mixture of Four diastereomers) | US9714234, 18
Type:
Small organic molecule
Emp. Form.:
C30H23FN4O4
Mol. Mass.:
522.5264
SMILES:
Cc1c(cccc1-n1c(=O)cc2c(F)cccn2c1=O)-c1ccc(C(N)=O)c2[nH]c3cc(CCO)ccc3c12 |(2.96,.56,;2.19,-.77,;.85,,;-.48,-.77,;-.48,-2.31,;.85,-3.08,;2.19,-2.31,;3.52,-3.08,;3.52,-4.62,;2.19,-5.39,;4.86,-5.39,;6.19,-4.62,;7.52,-5.39,;7.52,-6.93,;8.86,-4.62,;8.86,-3.08,;7.52,-2.31,;6.19,-3.08,;4.86,-2.31,;4.86,-.77,;.85,1.54,;2.19,2.31,;2.19,3.85,;.85,4.62,;.85,6.16,;2.19,6.93,;-.48,6.93,;-.48,3.85,;-1.94,4.33,;-2.85,3.08,;-4.38,2.92,;-5.01,1.51,;-6.54,1.35,;-7.44,2.6,;-8.98,2.44,;-4.1,.27,;-2.57,.43,;-1.94,1.83,;-.48,2.31,)|
Structure:
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