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Target
Tyrosine-protein kinase JAK2
Ligand
BDBM264157
Substrate
n/a
Meas. Tech.
Jak2 Tyrosine Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
740±n/a nM
Comments
extracted
Citation
 Ko, SS; Batt, DG; Bertrand, MB; Delucca, G; Langevine, CM; Liu, Q; Srivastava, AS; Watterson, SH Carbazole carboxamide compounds US Patent  US9714234 Publication Date 7/25/2017 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM264157
Synonyms:
US9714234, 32
Type:
Small organic molecule
Emp. Form.:
C30H23FN4O4
Mol. Mass.:
522.5264
SMILES:
COCc1ccc2c(c1)[nH]c1c(ccc(-c3cccc(c3C)-n3c(=O)cc4c(F)cccn4c3=O)c21)C(N)=O |(-8.96,1.8,;-7.48,2.2,;-6.39,1.11,;-4.9,1.51,;-3.99,.27,;-2.46,.43,;-1.84,1.83,;-2.74,3.08,;-4.27,2.92,;-1.84,4.33,;-.37,3.85,;.96,4.62,;2.3,3.85,;2.3,2.31,;.96,1.54,;.96,,;-.37,-.77,;-.37,-2.31,;.96,-3.08,;2.3,-2.31,;2.3,-.77,;3.63,,;3.63,-3.08,;3.63,-4.62,;2.3,-5.39,;4.96,-5.39,;6.3,-4.62,;7.63,-5.39,;7.63,-6.93,;8.96,-4.62,;8.96,-3.08,;7.63,-2.31,;6.3,-3.08,;4.96,-2.31,;4.96,-.77,;-.37,2.31,;.96,6.16,;2.3,6.93,;-.37,6.93,)|
Structure:
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