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Target
Prokineticin receptor 1
Ligand
BDBM349636
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
50.0±n/a nM
Citation
 Mitchell, P; Teall, M Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders US Patent  US10335402 Publication Date 7/2/2019 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM349636
Synonyms:
2-(4-Chlorophenyl)-2-(1-((3,5-diethyl-1H-pyrazol-4-yl) sulfonyl)piperidin-4-ylidene)acetonitrile | US10208016, Compound of Example 6 | US10335402, Example 6
Type:
Small organic molecule
Emp. Form.:
C20H23ClN4O2S
Mol. Mass.:
418.94
SMILES:
CCc1n[nH]c(CC)c1S(=O)(=O)N1CCC(CC1)=C(C#N)c1ccc(Cl)cc1 |(-7.76,-.91,;-6.27,-.51,;-5.5,.83,;-6.41,2.07,;-5.5,3.32,;-4.04,2.84,;-2.7,3.61,;-1.37,2.84,;-4.04,1.3,;-2.55,.9,;-2.15,2.39,;-2.95,-.58,;-1.06,.51,;.03,1.59,;1.52,1.2,;1.91,-.29,;.83,-1.38,;-.66,-.98,;3.4,-.69,;3.8,-2.18,;4.2,-3.67,;4.49,.4,;5.98,,;7.07,1.09,;6.67,2.58,;7.76,3.67,;5.18,2.98,;4.09,1.89,)|
Structure:
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