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Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM40281
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
18728.9±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM40281
Synonyms:
4-Amino-2-[(3-cyano-4,5-dimethyl-thiophen-2-ylcarbamoyl)-methylsulfanyl]-pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-[[2-[(3-cyano-4,5-dimethyl-2-thienyl)amino]-2-keto-ethyl]thio]pyrimidine-5-carboxylic acid ethyl ester | 4-amino-2-[[2-[(3-cyano-4,5-dimethyl-2-thiophenyl)amino]-2-oxoethyl]thio]-5-pyrimidinecarboxylic acid ethyl ester | MLS000030915 | SMR000001870 | cid_655387 | ethyl 4-amino-2-[2-[(3-cyano-4,5-dimethylthiophen-2-yl)amino]-2-oxoethyl]sulfanylpyrimidine-5-carboxylate | ethyl 4-azanyl-2-[2-[(3-cyano-4,5-dimethyl-thiophen-2-yl)amino]-2-oxidanylidene-ethyl]sulfanyl-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H17N5O3S2
Mol. Mass.:
391.468
SMILES:
CCOC(=O)c1cnc(SCC(=O)Nc2sc(C)c(C)c2C#N)nc1N
Structure:
Search PDB for entries with ligand similarity: