Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase BAP1
Ligand
BDBM40282
Substrate
n/a
Meas. Tech.
BAP1 Enzyme inhibitors Dose Response Confirmation
IC50
17282±n/a nM
Citation
 PubChem, PC BAP1 Enzyme inhibitors Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms:
BAP1 | BAP1_HUMAN | KIAA0272 | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) (Cerebral protein 6).
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80364.15
Organism:
Homo sapiens (Human)
Description:
gi_68565074
Residue:
729
Sequence:
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAPSHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
  
Inhibitor
Name:
BDBM40282
Synonyms:
3-[(1-tert-butyl-1,2,3,4-tetrazol-5-yl)-[4-(furan-2-ylcarbonyl)piperazin-1-yl]methyl]-8-methyl-1H-quinolin-2-one | 3-[(1-tert-butyl-5-tetrazolyl)-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-8-methyl-1H-quinolin-2-one | 3-[(1-tert-butyltetrazol-5-yl)-[4-(2-furoyl)piperazino]methyl]-8-methyl-carbostyril | 3-[(1-tert-butyltetrazol-5-yl)-[4-(furan-2-carbonyl)piperazin-1-yl]methyl]-8-methyl-1H-quinolin-2-one | 3-{(1-tert-Butyl-1H-tetrazol-5-yl)-[4-(furan-2-carbonyl)-piperazin-1-yl]-methyl}-8-methyl-1H-quinolin-2-one | MLS000032644 | SMR000003361 | cid_655555
Type:
Small organic molecule
Emp. Form.:
C25H29N7O3
Mol. Mass.:
475.5429
SMILES:
Cc1cccc2cc(C(N3CCN(CC3)C(=O)c3ccco3)c3nnnn3C(C)(C)C)c(=O)[nH]c12
Structure:
Search PDB for entries with ligand similarity: