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Target
Cathepsin B
Ligand
BDBM31040
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
71±7 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM31040
Synonyms:
1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000027832 | SMR000008919 | US9073941, 602 | cid_647501
Type:
Small organic molecule
Emp. Form.:
C14H13N5O2
Mol. Mass.:
283.2853
SMILES:
CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1
Structure:
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