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Target
Cathepsin B
Ligand
BDBM41109
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM41109
Synonyms:
1-(2,3-dimethylphenyl)-4-{[1-(1H-imidazol-4-ylsulfonyl)piperidin-4-yl]carbonyl}piperazine | MLS000092067 | SMR000026979 | [4-(2,3-dimethylphenyl)-1-piperazinyl]-[1-(1H-imidazol-5-ylsulfonyl)-4-piperidinyl]methanone | [4-(2,3-dimethylphenyl)piperazin-1-yl]-[1-(1H-imidazol-5-ylsulfonyl)piperidin-4-yl]methanone | [4-(2,3-dimethylphenyl)piperazino]-[1-(1H-imidazol-5-ylsulfonyl)-4-piperidyl]methanone | cid_3239534
Type:
Small organic molecule
Emp. Form.:
C21H29N5O3S
Mol. Mass.:
431.552
SMILES:
Cc1cccc(N2CCN(CC2)C(=O)C2CCN(CC2)S(=O)(=O)c2c[nH]cn2)c1C
Structure:
Search PDB for entries with ligand similarity: