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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM42267
Substrate
n/a
Meas. Tech.
Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity
EC50
>50000±n/a nM
Citation
 PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay (2008)[AID] 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase)
Type:
Enzyme
Mol. Mass.:
59724.64
Organism:
Homo sapiens (Human)
Description:
The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:
536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM42267
Synonyms:
2-[2-(benzotriazol-1-yl)ethanoyl-prop-2-enyl-amino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)ethanamide | 2-[Allyl-(2-benzotriazol-1-yl-acetyl)-amino]-2-(2,4-dimethoxy-phenyl)-N-(2-methoxy-ethyl)-acetamide | 2-[[2-(1-benzotriazolyl)-1-oxoethyl]-prop-2-enylamino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)acetamide | 2-[[2-(benzotriazol-1-yl)acetyl]-prop-2-enylamino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)acetamide | 2-[allyl-[2-(benzotriazol-1-yl)acetyl]amino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)acetamide | MLS000031807 | SMR000005235 | cid_645363
Type:
Small organic molecule
Emp. Form.:
C24H29N5O5
Mol. Mass.:
467.5176
SMILES:
COCCNC(=O)C(N(CC=C)C(=O)Cn1nnc2ccccc12)c1ccc(OC)cc1OC
Structure:
Search PDB for entries with ligand similarity: