Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM32279
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
1510±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM32279
Synonyms:
4-(4-carbethoxyanilino)quinazoline-2-carboxylic acid ethyl ester | 4-(4-ethoxycarbonylanilino)-2-quinazolinecarboxylic acid ethyl ester | MLS000519322 | SMR000129741 | cid_1192535 | ethyl 4-(4-ethoxycarbonylanilino)quinazoline-2-carboxylate | ethyl 4-[(4-ethoxycarbonylphenyl)amino]quinazoline-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4
Mol. Mass.:
365.3826
SMILES:
CCOC(=O)c1ccc(Nc2nc(nc3ccccc23)C(=O)OCC)cc1
Structure:
Search PDB for entries with ligand similarity: