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Target
Apoptosis regulator Bcl-2
Ligand
BDBM33102
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
980±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33102
Synonyms:
MLS000571745 | N-ethyl-N-(1-hydroxy-3,4-diketo-2-naphthyl)propionamide | N-ethyl-N-(1-hydroxy-3,4-dioxo-2-naphthalenyl)propanamide | N-ethyl-N-(1-hydroxy-3,4-dioxonaphthalen-2-yl)propanamide | N-ethyl-N-(3-hydroxy-1,4-dioxo-1,4-dihydro-2-naphthalenyl)propanamide | N-ethyl-N-[1-oxidanyl-3,4-bis(oxidanylidene)naphthalen-2-yl]propanamide | SMR000193757 | cid_2879069
Type:
Small organic molecule
Emp. Form.:
C15H15NO4
Mol. Mass.:
273.2839
SMILES:
CCN(C1C(=O)C(=O)c2ccccc2C1=O)C(=O)CC
Structure:
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