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Target
Ras-related protein Rab-2A
Ligand
BDBM43253
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
3448±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM43253
Synonyms:
MLS000119085 | N-(2-methylphenyl)-1-(8-quinolinylsulfonyl)-2-pyrrolidinecarboxamide | N-(2-methylphenyl)-1-quinolin-8-ylsulfonyl-pyrrolidine-2-carboxamide | N-(2-methylphenyl)-1-quinolin-8-ylsulfonylpyrrolidine-2-carboxamide | N-(o-tolyl)-1-(8-quinolylsulfonyl)pyrrolidine-2-carboxamide | SMR000096024 | cid_5309436
Type:
Small organic molecule
Emp. Form.:
C21H21N3O3S
Mol. Mass.:
395.475
SMILES:
Cc1ccccc1NC(=O)C1CCCN1S(=O)(=O)c1cccc2cccnc12
Structure:
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