Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43430
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
13560±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43430
Synonyms:
MLS000676810 | N-(2-cyclohexylsulfanylethyl)-4-methoxy-benzamide | N-(2-cyclohexylsulfanylethyl)-4-methoxybenzamide | N-[2-(cyclohexylthio)ethyl]-4-methoxy-benzamide | N-[2-(cyclohexylthio)ethyl]-4-methoxybenzamide | SMR000271821 | cid_2176259
Type:
Small organic molecule
Emp. Form.:
C16H23NO2S
Mol. Mass.:
293.424
SMILES:
COc1ccc(cc1)C(=O)NCCSC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: