Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM39435
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 activators: cell-based high throughput assay to measure STAT3 activation
EC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 activators: cell-based high throughput assay to measure STAT3 activation PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM39435
Synonyms:
2-[(3-cyano-6-pyridin-4-yl-2-pyridinyl)thio]acetic acid ethyl ester | 2-[[3-cyano-6-(4-pyridyl)-2-pyridyl]thio]acetic acid ethyl ester | MLS000027979 | SMR000038899 | cid_657961 | ethyl 2-(3-cyano-6-pyridin-4-yl-pyridin-2-yl)sulfanylethanoate | ethyl 2-(3-cyano-6-pyridin-4-ylpyridin-2-yl)sulfanylacetate
Type:
Small organic molecule
Emp. Form.:
C15H13N3O2S
Mol. Mass.:
299.348
SMILES:
CCOC(=O)CSc1nc(ccc1C#N)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: