Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43678
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 activators: cell-based high throughput assay to measure STAT3 activation
EC50
>55700±n/a nM
Citation
PubChem, PC Dose response counterscreen for STAT1 activators: cell-based high throughput assay to measure STAT3 activation PubChem Bioassay (2008)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM43678
Synonyms:
1-(4-chlorophenyl)-N-(2-oxolanylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine | 1-(4-chlorophenyl)-N-(oxolan-2-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine | MLS000100794 | SMR000017394 | [1-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-(tetrahydrofurfuryl)amine | cid_3717380
Type:
Small organic molecule
Emp. Form.:
C16H16ClN5O
Mol. Mass.:
329.784
SMILES:
Clc1ccc(cc1)-n1ncc2c(NCC3CCCO3)ncnc12
Structure:
