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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44413
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
1170±60 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44413
Synonyms:
(5E)-5-indol-3-ylidene-3-pyrazoline-3-carboxylic acid methyl ester | (5Z)-5-(3-indolylidene)-1,2-dihydropyrazole-3-carboxylic acid methyl ester | (5Z)-5-indol-3-ylidene-3-pyrazoline-3-carboxylic acid methyl ester | MLS000066006 | SMR000079439 | cid_5498390 | methyl (5Z)-5-indol-3-ylidene-1,2-dihydropyrazole-3-carboxylate | methyl 3-(1H-indol-3-yl)-1H-pyrazole-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C13H11N3O2
Mol. Mass.:
241.2453
SMILES:
COC(=O)c1cc(n[nH]1)-c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: