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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM46046
Substrate
n/a
Meas. Tech.
SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM46046
Synonyms:
2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(3-methoxy-4-oxidanyl-phenyl)ethanone;hydrochloride | 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(4-hydroxy-3-methoxyphenyl)ethanone;hydrochloride | 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-1-(4-hydroxy-3-methoxyphenyl)ethanone;hydrochloride | 2-[(4,6-dimethylpyrimidin-2-yl)thio]-1-(4-hydroxy-3-methoxy-phenyl)ethanone;hydrochloride | CHEMBL596810 | MLS-0315844.0001 | cid_25067475
Type:
Small organic molecule
Emp. Form.:
C15H16N2O3S
Mol. Mass.:
304.364
SMILES:
COc1cc(ccc1O)C(=O)CSc1nc(C)cc(C)n1
Structure:
Search PDB for entries with ligand similarity: