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Target
Ion channel NompC
Ligand
BDBM46770
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel N1 (TRPN1)
EC50
507±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel N1 (TRPN1) PubChem Bioassay (2010)[AID] 
Target
Name:
Ion channel NompC
Synonyms:
transient receptor potential cation channel, subfamily N, member 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
175824.78
Organism:
Danio rerio
Description:
Q7T1G6
Residue:
1614
Sequence:
MSESSCVSGAPQRLVPLALRGEWMALEQKIKTLERGDPDILQCDEESGMSLLMLAVRESRLSVLDRLLELGANPSDKTKDGRSALHIAAAHSKDEIVKLLVRKTDPNSPAGPNDQLPLHYAASRSTGGLAVVQTLLKFSSKDARLTPDKNGCLPLLLAAEAGNVGIVRELLSSQSEPQIRAAKTANGDTALHICCRRRDVEMAKILVEFGANPDSQNDEGQTPLHIAAHEGDENMLKFLYLCKANANISDKMDRSPLHIAAERGHTNVVEILTEKFRSCVLARTKDGNTLLHIASQCGHPTTALSFLRKGVPLHMPNKSGAVCLHAAAKRGHTAVVKALLQKGAHVDAAARDGQTALHIAVENCRPQVVQMLLGFGAHVQLRGGKAQETPLHISARVKEGERAAEMLLKSGAEVNAEQENGETALHVAARHGSLQMIRALIQEGGDPRWRSRVGESPLHVAVRHCHAHVVQEILTFLTNEKSRRDAELCVCEGNQDGETALHLAAELRTDALHQPEEDITIIQILMEHQADITAVTRQTGETPLHYSARVGNTAVLQEMLRNVPTNQIQTAINKHSKNGWSPLLLAADQGHTEVVKILLQNNARVDVFDEEGKAAIHLAAQRGHQDIVDVLLSQKAFVNAKTKQGLTPLHLSAQNGSARLVRLLVENHQASVDALSLRKQTPLHLAAMSGQLDVCSSLLNLRADITATDSRGQTPLHLAAESDHSEVVKLFLRLRPELSTLANEDGSTCTHIAAAKGSVSVIRELLMFNQGGVGTLNHKAHGLCPLHLAAAGGHAEVVKVLLEAGASVTEEDAEGMTAVHLAAKHGHTHILEVLRGSVPLKIQSSKTGFTALHVAASFGQMNFVREILTKVPATIRSEFPTISGKDDIKRQQPLAESGFTPLHLASQSGHESVVRLLLNCPGVQADAETNIQGSSPLHLAAQSGHTAVVGLLLSRSSSLLHQADRRGRSALHLAAAHGHVDMVRVLLGQGAEINHTDMSGWTALHYAAEAGCLEVLLFLVESGASACAECHGGRTPLQYAAQQNHESAVIFLLRREKNTLRLLDDKKFIFNLMVCGRMNDNLSLEELVLHTSAPLDTAVRLSRALTLCALREKERSVDLQAAAHHCELMASDLLSLSASAGGQGAGAGPILRALDHRGLSVLDCLIEGRQKGVVSQPAVQTYLTEVWCGGLQWDSWKILLLFCCLLLCPPLWLLLALPLTHSFNTIPIVKFMSHLVSHIFLLTLFILTIVYPPVSPLSQARLMPSWSECLLLIWLCGMLVSELTFPGERTGLAWIRLLLLGFSAAALLCHLLAVFTQWWPPTHLHCLFARNVLLAVAMTLGFIQLLEFLTFHHLFGPWAIIIRDLIKDLCRFAVILMLFHTAFTLSLTALCQPLYPQEQHNTTTEVTVPGPLNMSVLLFFALFGLTEPDKIPDVDRSPPATAVLAKMVFGVYLVVTFIVLINLLIAMMSDTYQRIQAQSDTEWKFGRAVLIRDMSRKSGIPSPFNLFTNLFYSVKVVCKRAGKMCSSESRDVMNEDEDAEGLSESRSLDLLSQASVSGIRGNKRTQILPEGGQISLAHSGGHVRVENVADWPSVVQQFLSQRRQRDRSTAERDE
  
Inhibitor
Name:
BDBM46770
Synonyms:
(2E,5E)-2-[4-(dimethylamino)benzylidene]-5-(2-methylpropylidene)cyclopentanone | (2E,5E)-2-[[4-(dimethylamino)phenyl]methylidene]-5-(2-methylpropylidene)-1-cyclopentanone | (2E,5E)-2-[[4-(dimethylamino)phenyl]methylidene]-5-(2-methylpropylidene)cyclopentan-1-one | MLS000580632 | SMR000204795 | cid_12004767
Type:
Small organic molecule
Emp. Form.:
C18H23NO
Mol. Mass.:
269.3813
SMILES:
CC(C)C=C1CCC(=Cc2ccc(cc2)N(C)C)C1=O |w:3.2,8.8|
Structure:
Search PDB for entries with ligand similarity: