Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM41670
Substrate
n/a
Meas. Tech.
Fluorescence-based counterscreen assay for S1P4 agonists: Cell-based dose response high throughput screening assay to identify agonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1)
EC50
7880±n/a nM
Citation
 PubChem, PC Fluorescence-based counterscreen assay for S1P4 agonists: Cell-based dose response high throughput screening assay to identify agonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1) PubChem Bioassay (2010)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM41670
Synonyms:
1-(2-methylphenyl)-2,5-bis(oxidanylidene)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile | 1-(2-methylphenyl)-2,5-dioxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarbonitrile | 1-(2-methylphenyl)-2,5-dioxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile | 2,5-diketo-1-(o-tolyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile | MLS000520593 | SMR000131004 | cid_9550812
Type:
Small organic molecule
Emp. Form.:
C19H12N4O2
Mol. Mass.:
328.3242
SMILES:
Cc1ccccc1-n1c2nc3ccccn3c(=O)c2cc(C#N)c1=O |(4.49,-1.6,;5.83,-2.35,;5.85,-3.89,;7.19,-4.65,;8.51,-3.86,;8.5,-2.32,;7.15,-1.57,;7.14,-.03,;8.51,.8,;9.85,.03,;11.18,.8,;12.56,-.03,;13.95,.76,;13.95,2.37,;12.56,3.16,;11.18,2.34,;9.85,3.11,;9.85,4.65,;8.51,2.34,;7.14,3.16,;5.74,2.37,;4.41,3.14,;3.08,3.92,;5.74,.76,;4.41,-.01,)|
Structure:
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