Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM47508
Substrate
n/a
Meas. Tech.
Fluorescence-based counterscreen assay for S1P4 agonists: Cell-based dose response high throughput screening assay to identify agonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1)
EC50
93500±n/a nM
Citation
 PubChem, PC Fluorescence-based counterscreen assay for S1P4 agonists: Cell-based dose response high throughput screening assay to identify agonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1) PubChem Bioassay (2010)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM47508
Synonyms:
1-[[(1E)-1-[2,7-bis(oxidanylidene)chromen-3-ylidene]ethyl]amino]thiourea | MLS000777400 | SMR000413856 | [[(1E)-1-(2,7-diketochromen-3-ylidene)ethyl]amino]thiourea | [[(1E)-1-(2,7-dioxo-1-benzopyran-3-ylidene)ethyl]amino]thiourea | [[(1E)-1-(2,7-dioxochromen-3-ylidene)ethyl]amino]thiourea | cid_5418014
Type:
Small organic molecule
Emp. Form.:
C12H11N3O3S
Mol. Mass.:
277.299
SMILES:
CC(NNC(N)=S)=c1cc2C=CC(=O)C=c2oc1=O |w:1.0,c:10,14|
Structure:
Search PDB for entries with ligand similarity: