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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265627
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
210±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265627
Synonyms:
(5r,8r)-8-(((R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)amino)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2-azaspiro[4.5]decan-1-one | US9718808, 78
Type:
Small organic molecule
Emp. Form.:
C25H30N2O6
Mol. Mass.:
454.5155
SMILES:
CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NC[C@H](O)c2ccc3C(=O)OCc3c2C)C1=O |r,wU:10.34,wD:13.17,18.20,t:1,(7.11,2.2,;7.88,.87,;7.4,-.6,;8.65,-1.5,;9.89,-.6,;9.42,.87,;10.19,2.2,;5.86,-.6,;5.38,-2.06,;3.84,-2.06,;3.37,-.6,;2.97,-2.08,;1.48,-2.48,;.39,-1.39,;.79,.09,;2.28,.49,;-1.15,-1.39,;-2.48,-.62,;-3.81,-1.39,;-3.81,-2.93,;-5.15,-.62,;-5.15,.92,;-6.48,1.69,;-7.82,.92,;-9.28,1.39,;-9.28,2.93,;-10.19,.15,;-9.28,-1.1,;-7.82,-.62,;-6.48,-1.39,;-6.48,-2.93,;4.61,.31,;4.61,1.85,)|
Structure:
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