Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM266975
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
41.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM266975
Synonyms:
US9718808, 104
Type:
Small organic molecule
Emp. Form.:
C21H26N8O3
Mol. Mass.:
438.4829
SMILES:
C[C@H]1C[C@@]2(CC[C@@H](CC2)N(C)Cc2ccc(nn2)-n2cnnn2)C(=O)N1C1=CC(=O)OC1 |r,wU:3.25,1.0,wD:6.9,t:30,(6.4,-3,;5.63,-1.66,;4.09,-1.66,;3.61,-.2,;2.53,-1.29,;1.04,-.89,;.64,.6,;1.73,1.69,;3.22,1.29,;-.85,1,;-1.25,2.48,;-1.94,-.09,;-3.42,.31,;-4.51,-.78,;-6,-.38,;-6.4,1.1,;-5.31,2.19,;-3.82,1.79,;-7.89,1.5,;-9.13,.6,;-10.38,1.5,;-9.9,2.97,;-8.36,2.97,;4.86,.71,;4.86,2.25,;6.11,-.2,;7.59,.2,;8.07,1.66,;9.61,1.66,;10.38,3,;10.08,.2,;8.84,-.71,)|
Structure:
Search PDB for entries with ligand similarity: