Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM48996
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Assay
EC50
0.0168±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Assay PubChem Bioassay (2007)[AID] 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM48996
Synonyms:
1-(10,11-Dihydro-dibenzo[b,f]azepin-5-yl)-2-[5-(4-fluoro-phenoxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-ethanone | 1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-[[5-[(4-fluoranylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone | 1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-[[5-[(4-fluorophenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone | 1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-2-[[5-[(4-fluorophenoxy)methyl]-1,3,4-oxadiazol-2-yl]thio]ethanone | MLS000075436 | SMR000002883 | cid_654722
Type:
Small organic molecule
Emp. Form.:
C25H20FN3O3S
Mol. Mass.:
461.508
SMILES:
Fc1ccc(OCc2nnc(SCC(=O)N3c4ccccc4CCc4ccccc34)o2)cc1
Structure:
Search PDB for entries with ligand similarity: