Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM49574
Substrate
n/a
Meas. Tech.
Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response
EC50
1971±n/a nM
Citation
 PubChem, PC Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM49574
Synonyms:
(Z)-2-(1,3-benzothiazol-2-yl)-3-(2-furanyl)-2-propenenitrile | (Z)-2-(1,3-benzothiazol-2-yl)-3-(2-furyl)acrylonitrile | (Z)-2-(1,3-benzothiazol-2-yl)-3-(furan-2-yl)prop-2-enenitrile | (Z)-2-Benzothiazol-2-yl-3-furan-2-yl-acrylonitrile | MLS000589637 | SMR000219445 | cid_7441600
Type:
Small organic molecule
Emp. Form.:
C14H8N2OS
Mol. Mass.:
252.291
SMILES:
N#C\C(=C\c1ccco1)c1nc2ccccc2s1
Structure:
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