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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM243996
Substrate
n/a
Meas. Tech.
MAO-B Inhibitory Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
 Matsumoto, S; Hattori, Y; Toyofuku, M; Morimoto, S; Kojima, T; Kaku, T; Ito, M Cyclopropanamine compound and use thereof US Patent  US9718814 Publication Date 8/1/2017 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM243996
Synonyms:
N-(5-methyl-1,2- oxazol-3-yl)-5- ((1R,2R)-2- ((tetrahydro-2H- pyran-4-ylmethyl)- amino)cyclopropyl)- thiophene-3- carboxamide | US10053456, 81 | US10414761, Example 81 | US9718814, 81 | US9920047, 81
Type:
Small organic molecule
Emp. Form.:
C18H23N3O3S
Mol. Mass.:
361.459
SMILES:
Cc1cc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)no1 |r|
Structure:
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