Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM57221
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM57221
Synonyms:
3-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1-phenyl-thieno[2,3-c]pyrazole-5-carboxamide | 3-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1-phenylthieno[2,3-c]pyrazole-5-carboxamide | 3-methyl-N-(5-methyl-2-thiazolyl)-1-phenyl-5-thieno[2,3-c]pyrazolecarboxamide | 3-methyl-N-(5-methylthiazol-2-yl)-1-phenyl-thieno[2,3-c]pyrazole-5-carboxamide | MLS000565726 | SMR000152857 | cid_2102506
Type:
Small organic molecule
Emp. Form.:
C17H14N4OS2
Mol. Mass.:
354.449
SMILES:
Cc1cnc(NC(=O)c2cc3c(C)nn(-c4ccccc4)c3s2)s1
Structure:
Search PDB for entries with ligand similarity: