Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM57358
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM57358
Synonyms:
1-[[2-(3,4-dichlorophenyl)quinolin-4-yl]carbonylamino]-3-phenyl-urea | 1-[[2-(3,4-dichlorophenyl)quinoline-4-carbonyl]amino]-3-phenyl-urea | 1-[[2-(3,4-dichlorophenyl)quinoline-4-carbonyl]amino]-3-phenylurea | 1-[[[2-(3,4-dichlorophenyl)-4-quinolinyl]-oxomethyl]amino]-3-phenylurea | 2-{[2-(3,4-dichlorophenyl)-4-quinolinyl]carbonyl}-N-phenylhydrazinecarboxamide | MLS000545716 | SMR000159529 | cid_1012180
Type:
Small organic molecule
Emp. Form.:
C23H16Cl2N4O2
Mol. Mass.:
451.305
SMILES:
Clc1ccc(cc1Cl)-c1cc(C(=O)NNC(=O)Nc2ccccc2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: