Reaction Details Report a problem with these data
Target
Large T antigen
Ligand
BDBM47293
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
24730±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM47293
Synonyms:
(4Z)-4-[[5-(2-bromophenyl)-2-furanyl]methylidene]-3-methyl-5-isoxazolone | (4Z)-4-[[5-(2-bromophenyl)-2-furyl]methylene]-3-methyl-2-isoxazolin-5-one | (4Z)-4-[[5-(2-bromophenyl)furan-2-yl]methylidene]-3-methyl-1,2-oxazol-5-one | (4Z)-4-{[5-(2-bromophenyl)-2-furyl]methylene}-3-methylisoxazol-5(4H)-one | MLS000727735 | SMR000306432 | cid_16188836
Type:
Small organic molecule
Emp. Form.:
C15H10BrNO3
Mol. Mass.:
332.149
SMILES:
CC1=NOC(=O)\C1=C/c1ccc(o1)-c1ccccc1Br |t:1|
Structure:
Search PDB for entries with ligand similarity: