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Target
Large T antigen
Ligand
BDBM58996
Substrate
n/a
Meas. Tech.
Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits
EC50
<100±n/a nM
Citation
 PubChem, PC Identification of SV40 T antigen inhibitors: Cytotoxicity screen of selected hits PubChem Bioassay (2009)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM58996
Synonyms:
1-(3,4-dihydroxyphenyl)-2-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]ethanone | 1-(3,4-dihydroxyphenyl)-2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]ethanone | 1-(3,4-dihydroxyphenyl)-2-[4-(4-fluorophenyl)sulfonylpiperazino]ethanone | 1-(3,4-dihydroxyphenyl)-2-{4-[(4-fluorophenyl)sulfonyl]piperazin-1-yl}ethanone | 1-[3,4-bis(oxidanyl)phenyl]-2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]ethanone | MLS000673843 | SMR000315084 | cid_3674707
Type:
Small organic molecule
Emp. Form.:
C18H19FN2O5S
Mol. Mass.:
394.417
SMILES:
Oc1ccc(cc1O)C(=O)CN1CCN(CC1)S(=O)(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: